Abbreviations

Abbreviations

GMB

Adult glioblastoma

pHGG

Paediatric high-grade glioma

UNCAN

EU initiative for understanding cancer

MRI

Magnetic resonance imaging 

SOC

Standard of care

I/O

Immuno-oncology

TTF

Tumour treating fields

Results

Browse the scientific knowledge, tools and outputs generated by the project to advance data-driven precision medicine in glioblastoma.

Deliverables

All public deliverables produced by the project, including a summary of key findings and lead partners, are listed below and available for download.

D7.5 First conclusions of common annual meeting of the “Understanding (tumour-host interactions)” cluster (April 2025)

Key findings:

  • Outlines the content and conclusions of the first annual meeting, including agenda, minutes and action points
  • Summarises collaborative work conducted within each cluster strand and defines next steps for joint activities
  • Serves as a reference to monitor progress and guide future annual meetings across the U-THI-Clust

Lead partner: accelCH

Key findings:

  • Developed a joint cluster video and brochure to promote mission and activities of U-THI-Clust
  • Materials support unified communication and raise awareness of tumour-host interaction research
  • Outputs enhance outreach, accessibility and collaboration across the six cluster projects

Lead partner: accelCH

Key findings:

  • Identifies GDPR-related challenges in Material and Data Transfer Agreements across multi-partner projects
  • Proposes standardised templates, EU-level legal support and clearer guidance to reduce administrative burden
  • Recommends improved timing and guidance for deliverables such as the Data Management Plan

Lead partner: CPE

Key findings:

  • Establishes a joint strategy for collaboration across cluster projects, including data management and communication
  • Defines working groups and coordination mechanisms to align research and policy contributions
  • Identifies future collaboration opportunities such as joint publications, living labs and policy recommendations

Lead partner: KUL

Key findings:

  • Defines the strategy and implementation steps for stakeholder involvement, communication and dissemination
  • Establishes target groups, tools, channels and KPIs for outreach activities
  • Provides a modular and adaptable framework to maximise project impact over time

Lead partner: accelCH

Key findings:

  • Defines legal principles for conducting clinical trials under GDPR and Clinical Trial Regulation
  • Establishes joint controllership and responsibilities among clinical partners
  • Provides framework for data processing, informed consent and compliant data sharing

Lead partner: UDUS

Key findings:

  • Defines a harmonised clinical trial design across five immunotherapy trials
  • Establishes common patient population, intervention schemes and evaluation criteria
  • Provides the basis for ethical approval, trial protocols and EU clinical trial registration

Lead partner: UDUS

Publications

Peer-reviewed publications are listed and linked below.

Longitudinal tumor ecosystem mapping defines glioblastoma treatment trajectories

Vanmechelen, M., Nazari, P., Beckervordersandforth, J., Caprioli, C., Leunissen, D.J.G., Cole, B., Bravo González-Blas, C., Decraene, B., De Visser, Y., Shankar, G., Verduin, M., Pantano, D., Bevers, S., Moors, T., Zielinski, S., Telang, J., Sebastian, I., Messiaen, J., Van Herck, Y., Geens, E., Eekers, D.B.P., Claeys, A., Derweduwe, M., Zur Hausen, A., Chui, J., Bosisio, F.M., Weyns, F., Daenekindt, T., Oosterbos, C., Van Eyken, P., Govers, M., Mennens, F., Hovinga, K., De Vleeschouwer, S., Clement, P.M., Broen, M.P.G., Vooijs, M., Sciot, R., Antoranz, A., Pey, J., Speel, E.J., Hoeben, A., De Smet, F.
BioRxiv, March 2026

DOI: https://doi.org/10.64898/2026.03.04.709701
Access*: This article is a pre-print. It is open access but not yet peer-reviewed.

Leveraging hand-crafted radiomics on multicenter FLAIR MRI for predicting disability worsening in people with multiple sclerosis

Khan H., Woodruff H.C., Giraldo D.L., Werthen-Brabants L., Mali S.A., Amirrajab S., De Brouwer E., Popescu V., Van Wijmeersch B., Gerlach O., Sijbers J., Peeters L.M., Lambin P.
Frontiers in Neuroscience, October 2025

DOI: https://doi.org/10.3389/fnins.2025.1610401
Access: Open access

Improving Patient Engagement in Phase 2 Clinical Trials With a Trial-Specific Patient Decision Aid: Development and Usability Study

Halilaj I., Lieverse R., Oberije C., Hendriks L., Billiet C., Joye I., Van Eeckhout B., Wind A., Ankolekar A., Lambin P.
Journal of Medical Internet Research, 2025

DOI: https://doi.org/10.2196/71817
Access: Open access

Impact of synthetic data on training a deep learning model for lesion detection and classification in contrast-enhanced mammography

Van Camp A., Woodruff H.C., Cockmartin L., Lobbes M., Majer M., Balleyguier C., Marshall N.W., Bosmans H., Lambin P.
Journal of Medical Imaging, April 2025

DOI: https://doi.org/10.1117/1.JMI.12.S2.S22006
Access: Open access

Proactive process evaluation of precision medicine platforms: a roadmap

Cresswell K.
BMJ Health & Care Informatics, July 2025

DOI: https://doi.org/10.1136/bmjhci-2025-101434
Access: Open access

Pushing the boundaries of radiotherapy-immunotherapy combinations: highlights from the 7th immunorad conference

Laurent P.-A., André F., Bobard A., Deandreis D., Demaria S., Depil S., Eichmüller S.B., Fernandez-Palomo C., Foijer F., Galluzzi L., Galon J., Guckenberger M., Harrington K.J., Herrera F.G., Huber P.E., Italiano A., Karam S.D., Kroemer G., Lambin P., Leuschner C., Mantovani A., Meylan E., Mondini M., Pittet M.J., Pouget J.-P., Remon J., Sørensen C.S., Sotiriou C., Vanpouille-Box C., Weichselbaum R.R., Welsh J.W., Zitvogel L., Formenti S.C., Deutsch E.
OncoImmunology, 2025

DOI: https://doi.org/10.1080/2162402X.2024.2432726
Access: Open access

An automated toolbox for microcalcification cluster modeling for mammographic imaging

Van Camp A., Punter E., Houbrechts K., Cockmartin L., Prevos R., Marshall N.W., Woodruff H.C., Lambin P., Bosmans H.
Medical Physics, February 2025

DOI: https://doi.org/10.1002/mp.17521
Access: Open access

The conundrum of CD8+ T cell trajectories in low antigenic tumors: How to overcome a hypofunctional state distinct from antigen-driven exhaustion?

Datsi A., Sorg R.V., Garg A.D.
Genes & Immunity, October 2024

DOI: https://doi.org/10.1038/s41435-024-00299-y
Access: Open access

Trial watch: anticancer vaccination with dendritic cells

Borges F., Laureano R.S., Vanmeerbeek I., Sprooten J., Demeulenaere O., Govaerts J., et al.
OncoImmunology, 2024

DOI: https://doi.org/10.1080/2162402X.2024.2412876
Access: Open access